"Clicking notification doesnt open the app that triggered the notification"or
"zero reaction on clicks when a new notification pops up"I had this problem because I had a previous version of Growl before upgrading.
To restore this very handy functionality, install the Growl Version Detective (http://growl.info/downloads#generaldownloads currently 1.2.2) and upgrade the Framework version on your app like shown below.
After updating the Framework version for iTerm and Adium, I was able to click on the Growl notification and have that action restore the focus to the respective applications.